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Our studies reveal a new molecular glue that recruits its target protein directly to DDB1 to bypass the requirement of a substrate-specific receptor, presenting a new strategy for targeted protein degradation. Keywords: CDK12/CCNK; biochemistry; chemical biology; human; molecular glue; target identification; targeted protein degradation.
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Las Vegas has a lively craft beer scene, especially in the Arts District. Here's where to find a unique pint. Fancy clubs and bars lining the Strip tend to get all the accolades and headlines, but there is a surprisingly robust craft beer scene in Las Vegas that frequently flies under the radar.
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